Dual Case Report of Hemoglobin SC Disease in Pregnancy

Background: Hemoglobin SC disease (HbSC) is second only to sickle cell anemia (SCA) as the most common hemoglobinopathy. Pregnant women with SCA are known to be at high risk of obstetrical complications and perinatal mortality as well as sickle related complications. The aim of this study is to review the morbidity and mortality associated with pregnancies complicated by haemoglobinopathies. Case(s): We describe two cases of HbSC disease complicating pregnancy with episodes painful crises and anemia. Both patients were managed with hydration, blood transfusions and analgesia. One of the pregnancies was complicated by other co-morbidities cholestasis of pregnancy, preeclampsia and postpartum hemorrhage. Conclusion: Painful crises, preterm delivery and preeclampsia are frequently complicate pregnancy affected by SCD. Although HbSC genotype typically presents a more benign clinical evolution than HbSS, both may present with complications of similar severity. Parturients with SCD regardless of their genotype should be managed by a multidisciplinary approach and carefully monitored to limit maternal and fetal complications.