Key result
Subcutaneous obesity is not linked to higher muscle sympathetic nerve activity compared to nonobese men.
Why the study?
The relation between obesity phenotypes, abdominal visceral fat, and muscle sympathetic nerve activity (MSNA) remains unclear, particularly regarding the role of leptin in sympathetic activation.
Population
24 sedentary men including 15 nonobese and 9 subcutaneously obese men
Comparison
Subcutaneously obese men vs nonobese men with similar abdominal visceral fat
Design
Cross-sectional study with MSNA, body composition, and abdominal fat distribution measurements
Authors
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Does not support sympathetic-targeted interventions in subcutaneous obesity; leaves open visceral fat as the key driver in prospective studies.
Cross-Sectional (n=24)
Absolute Event Rate: 23% vs 24%
p-value: p=> 0.05
Subcutaneous obesity is not associated with increased sympathetic neural activation when abdominal visceral fat levels are similar to nonobese individuals, suggesting the relationship between obesity and sympathetic activity is phenotype-dependent.
Alvarez et al. (2004) conducted a cross-sectional in Subcutaneous obesity (n=24). Subcutaneous obesity vs. Nonobese was evaluated on Muscle sympathetic nerve activity (MSNA) (p=> 0.05). Subcutaneous obesity was not associated with higher muscle sympathetic nerve activity compared to nonobese men (23 vs. 24 bursts/min; P > 0.05).
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