Key result
Substance P injection in dogs transiently increases pulpal blood flow ~66% before rapidly decreasing.
Why the study?
The effects of substance P on pulpal blood flow and its biphasic response in a low-compliance system were not fully characterized.
p-value: p=<0.02
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Substance P may modulate canine pulpal flow; leaves open its role in human pulpal vasoregulation.
Kim et al. (1988) studied Pulpal blood flow response in dogs. Substance P vs. Control values was evaluated on Pulpal blood flow (PBF) (p=<0.02). Close injection of substance P into the maxillary artery of dogs caused an immediate 66% increase in pulpal blood flow (p<0.02) followed by a 53% decrease at 30 seconds (p<0.05).
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