Key result
Hyperbaric oxygen therapy linked to reduced paroxysmal sympathetic hyperactivity and restored consciousness in post-CPR patients.
Why the study?
Paroxysmal sympathetic hyperactivity (PSH) after cardiopulmonary resuscitation is a serious clinical syndrome with limited reports on hyperbaric oxygen therapy (HBOT) as a treatment.
Does hyperbaric oxygen therapy improve paroxysmal sympathetic hyperactivity in patients post-cardiopulmonary resuscitation?
Case Report (n=4)
No
Does hyperbaric oxygen therapy improve paroxysmal sympathetic hyperactivity in patients post-cardiopulmonary resuscitation?
Hyperbaric oxygen therapy may alleviate paroxysmal sympathetic hyperactivity and promote awakening in patients after cardiopulmonary resuscitation.
Background After cardiopulmonary resuscitation (CPR), paroxysmal sympathetic hyperactivity (PSH) will appear due to extensive brain injury. PSH is a serious clinical syndrome, and it is often treated with drugs. However, the application of hyperbaric oxygen in the treatment(HBOT) of PSH is rarely reported in the literature.We aimed to investigate the clinical effects of single-chamber pure oxygen treatment on PSH following CPR. Methods We retrospectively analysed clinical data of four patients treated at our hospital who developed signs of PSH post-CPR and received HBOT at an early stage to assess the clinical effects of HBOT on PSH. Results Following 3–4 HBOT sessions, signs of PSH were substantially diminished, and patients’ Clinical Symptom Scale scores decreased significantly. The time to awakening was 34, 25, 38, and 28 days for cases 1–4, respectively. Conclusions HBOT alleviated PSH, reduced brain damage, and promoted a return to full consciousness. HBOT efficacy was significant in these patients, and promoting HBOT in the clinical setting is recommended.
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Li et al. (2023) conducted a case report in Paroxysmal sympathetic hyperactivity after cardiopulmonary resuscitation (n=4). Hyperbaric oxygen therapy was evaluated on Alleviation of PSH signs and time to awakening. Hyperbaric oxygen therapy alleviated signs of paroxysmal sympathetic hyperactivity, reduced brain damage, and promoted a return to full consciousness in four post-cardiopulmonary resuscitation patients.
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