Key result
APPV CH-GX2016 genome shares ~89% homology with reference strains, confirming novel pestivirus in Chinese pigs.
Why the study?
Atypical porcine pestivirus (APPV) is a novel pestivirus associated with congenital tremor type A-II, but its presence and genetic characteristics in pigs in China were not established.
Answers are grounded in this paper and cite their sources.
Identifies and characterizes a novel atypical porcine pestivirus strain in China, expanding the known geographic distribution of the virus.
Atypical porcine pestivirus (APPV) has been considered a novel pestivirus and causative agent of congenital tremor type A-II. An APPV CH-GX2016 strain was characterized from newly born piglets with clinical symptoms of congenital tremor in Guangxi, China. The genome of APPV CH-GX 2016 strain was 11,475 bp in length and encoded a polyprotein composed of the 3,635 amino acids. This genome sequence exhibited 88.0% to 90.8% nucleotide sequence homology with other APPV reference sequences in GenBank. Phylogenetic analysis further showed that APPV CH-GX is a novel pestivirus compared with previously described classical pestivirus strains. Therefore, APPV is present in pigs in China.
No takes yet. Share an insight, caveat, or question.
Zhang et al. (2017) studied Congenital tremor type A-II. Atypical porcine pestivirus (APPV) CH-GX2016 strain vs. Other APPV reference sequences and classical pestivirus strains was evaluated on Genomic sequence homology and phylogenetic relationship (88.0% to 90.8% nucleotide sequence homology). The APPV CH-GX2016 strain genome exhibited 88.0% to 90.8% nucleotide sequence homology with other APPV reference sequences, confirming the presence of this novel pestivirus in pigs in China.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: