Key result
Atypical porcine pestivirus RNA was detected in 43.6% (95% CI 27.8-60.4%) of piglets with congenital tremor, whereas no viral RNA was detected in healthy piglets.
Cross-Sectional (n=165)
Yes
Absolute Event Rate: 43.6% vs 0%
The study identifies a high prevalence of APPV in piglets with congenital tremor in southwest China and discovers a novel APPV genotype.
APPV association with congenital tremor supports viral role in piglets; leaves open causality and generalizability pending prospective studies.
Atypical porcine pestivirus (APPV) causes congenital tremor (CT) in piglets and has a wide geographical distribution. In this study, we evaluated APPV prevalence using 165 piglet sera from southwest China. Viral RNA was detectable by qRT-PCR in 43.6 % (17/39, 95 % CI 27.8-60.4 %) of piglets with CT, while viral RNA was not detected in the sera of any healthy piglets. The seven complete APPV genomes were obtained from distinct farms and were 11 269-11 459 nucleotides in length. The genomes of the seven strains shared 82.8-98 % identity with the APPV reference strains. Phylogenetic analysis of the complete genomes as well as E2 and Nrpo sequences revealed that the seven APPVs clustered into two groups: four strains belonged to genogroups A and D and three strains belonged to a novel APPV genotype, tentatively called genogroup E. This study provides important insights into the epidemiological features and genetic diversity of APPV.
No takes yet. Share an insight, caveat, or question.
Zhou et al. (2018) conducted a cross-sectional in Congenital tremor / Atypical porcine pestivirus (APPV) (n=165). Congenital tremor vs. Healthy piglets was evaluated on APPV viral RNA detection by qRT-PCR (95% CI 27.8-60.4). Atypical porcine pestivirus RNA was detected in 43.6% (95% CI 27.8-60.4%) of piglets with congenital tremor, whereas no viral RNA was detected in healthy piglets.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: