Key result
LBBAP linked to severe deterioration of LV function in a rare case report.
Why the study?
Left bundle branch area pacing (LBBAP) is a promising alternative to conventional pacing methods, but severe deterioration of left ventricular function after LBBAP is rarely reported.
Case Report (n=1)
This case report highlights a rare complication of severe left ventricular function deterioration following left bundle branch area pacing, despite its general association with physiological pacing.
Case illustrates LBBAP feasibility in narrow-QRS patients; hypothesis-generating for PICM prevention, requiring prospective trials.
Left bundle branch area pacing (LBBAP) has emerged as a promising alternative to conventional right ventricular pacing (RVP) and biventricular pacing (BVP), for treating patients with narrow QRS complexes 1. LBBAP provides physiological pacing by depolarizing ventricles via the Purkinje system, preserving cardiac electrical and mechanical synchrony, which is often disrupted with conventional pacing methods resulting in pacemaker induced cardiomyopathy (PICM)1. Several large observational studies have shown superior outcomes in reducing heart failure related hospitalizations and all-cause mortality for patients undergoing LBBAP vs RVP2,3.
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Sachin Nayyar (2025) conducted a case report in Severe deterioration of left ventricular function (n=1). Left bundle branch area pacing (LBBAP) was evaluated. Left bundle branch area pacing was associated with severe deterioration of left ventricular function in a rare case report.
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