Key result
High Ang-2 expression linked to shorter overall survival and lymph-node metastasis in colorectal cancer.
Why the study?
The relationships between expressions of Ang-1, Ang-2, and Tie-2 receptor and clinical parameters or overall survival in colorectal cancer patients were unclear.
Observational (n=114)
No
p-value: p=0.016
High expression of Ang-2 is correlated with lymph-node metastasis and poor overall survival in colorectal cancer, suggesting its utility as a prognostic marker.
Ang-2/Ang-1 imbalance was associated with colorectal cancer prognosis; leaves open its added value for risk stratification.
PURPOSE: Angiopoietin-1 (Ang-1) plays a crucial role in vascular and hematopoietic development, mainly through its cognate receptor, Tie-2. Increased levels of Ang-2 have been shown to be correlated with abnormal tumor angiogenesis in several malignancies. Hence, we estimated the increased expression of Ang-2 relative to Ang-1 in patients with colorectal cancer and correlated our finding with prognosis in order to investigate the relationships between the expressions of Ang-1/Ang-2/Tie-2 receptor and the clinical parameters or overall survival of such patients. METHODS: We retrospectively analyzed 114 tissue samples from patients with colorectal cancer by using immunohistochemistry (IHC) to examine Ang-1, Ang-2, and Tie-2 expressions and to investigate the relationship between those expressions and clinical parameters or overall survival of such patients. A Western blot analysis was used for Ang-2 expression. RESULTS: IHC staining showed a link between Ang-1 and Tie-2 (P = 0.018), as well as meaningful correlations between Ang-2 and Tie-2 receptor (P = 0.022) and between lymph-node metastasis and Ang-2 (P = 0.025). The stronger the IHC staining for Ang-2 expression was, the shorter the cumulative survival was (P = 0.016). CONCLUSION: A relationship was found to exist between Ang-2 and Tie-2 expressions. The Ang-2 was correlated with lymph-node metastasis, and high expression of Ang-2 was indicative of poor overall survival. These findings suggest that Ang-2 is a useful prognostic marker in the management of patients with colorectal cancer. In addition, we suggest that Ang/Tie-2 signaling plays an important role in the progression of colorectal cancer.
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Hong et al. (2017) conducted an observational in Colorectal cancer (n=114). High Angiopoietin-2 (Ang-2) expression vs. Low Ang-2 expression was evaluated on Overall survival (p=0.016). High expression of Ang-2 was significantly associated with shorter overall survival (P = 0.016) and correlated with lymph-node metastasis in patients with colorectal cancer.
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