Why the study?
Do serum concentrations of Ang-1, Ang-2, and Tie-2 have prognostic value for survival or predict response to chemotherapy in patients with advanced NSCLC?
Do serum concentrations of Ang-1, Ang-2, and Tie-2 have prognostic value for survival or predict response to chemotherapy in patients with advanced NSCLC?
Serum levels of Ang-1, Ang-2, and Tie-2 do not appear to have clinical utility for predicting survival or chemotherapy response in patients with advanced NSCLC.
Serum Ang-1, Ang-2, and Tie-2 lack prognostic or predictive utility in advanced NSCLC; hypothesis-generating and requires validation in larger cohorts.
This pilot study was conducted to investigate the prognostic role and the effects of chemotherapy on serum angiogenic factors enzyme-linked immunosorbent assay consisting of Angiopoietin-1 and 2 (Ang-1, Ang-2) and their receptor Tie-2 in patients with advanced stage nonsmall cell lung cancer (NSCLC). Concentration of Ang-2 was higher in NSCLC (n= 40) than in healthy people (n= 15), whereas Ang-1 and Tie-2 were comparable. In our opinion determination of Ang-1, Ang-2, and Tie-2 concentrations have no clinical significance in the prognosis of the survival time in lung cancer and can not be used as a predictor of response to the chemotherapy.
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Naumnik et al. (2009) studied this question.
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