Why the study?
Angiopoietin-2 has been implicated in cancer development, but its impact on the development, dissemination, and 5-year overall survival of NSCLC and SCLC required examination.
Does baseline Ang-2 serum concentration predict 5-year overall survival in patients with NSCLC and SCLC?
Does baseline Ang-2 serum concentration predict 5-year overall survival in patients with NSCLC and SCLC?
High baseline Ang-2 serum concentration is an independent predictor of poor 5-year overall survival in patients with stage IIIβ NSCLC.
Serum Ang-2 may aid risk stratification in lung cancer; leaves open its role as a therapeutic target.
Angiopoietin-2 (Ang-2) has been implicated in the development of several types of cancer, including lung malignancy. In the present study, we examined the impact of Ang-2 serum concentration on the development, dissemination, and 5-year overall survival of NSCLC and SCLC. A total of 99 patients with lung cancer were tested. The OS of NSCLC and SCLC patients was estimated using Kaplan−Meier curves and compared through log-rank test. The median serum level of Ang-2 at baseline in both NSCLC and SCLC patients was significantly higher than that of controls (p < 0.0001). The Ang-2 serum concentration was not related to metastasis, neither in NSCLC nor in SCLC cases. The OS was found to be significantly shorter for stage IIIβ NSCLC patients with a high baseline Ang-2 serum concentration (p = 0.012), while Cox regression analysis showed that Ang-2 is a significant independent factor for poor prognosis for stage IIIβ NSCLC (hazard ratio = 2.97, 95% CI: 1.05−8.40, p = 0.04). The concentration of Ang-2 has no impact on the prognosis of SCLC. Ang-2 could be considered as a significant molecular marker that enables the prediction of NSCLC and SCLC development, and is involved in the poor prognosis of stage IIIβ NSCLC.
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Nikolakopoulou et al. (2022) studied this question.
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