Key result
Apical ballooning syndrome is not associated with higher neuroticism than the normal population.
Why the study?
Apical ballooning syndrome is typically associated with antecedent stress and premorbid affective disorders, but the levels of neuroticism and stress vulnerability in these patients were unclear.
Do patients with apical ballooning syndrome have elevated levels of neuroticism and greater vulnerability to stress compared to the general population?
Population
53 patients with apical ballooning syndrome from the Mayo Clinic ABS prospective follow-up registry
Comparison
NEO-PI-3 personality inventory scores vs US normative sample
Design
Cross-sectional study
Authors
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ABS patients lack elevated neuroticism; challenges prior affective disorder links and leaves predisposing mechanisms open for prospective study.
Cross-Sectional (n=53)
No
Do patients with apical ballooning syndrome have elevated levels of neuroticism and greater vulnerability to stress compared to the general population?
Absolute Event Rate: 48% vs 50%
p-value: p=0.18
Contrary to prior hypotheses, patients with apical ballooning syndrome do not exhibit higher levels of neuroticism or stress vulnerability compared to the general population.
Scantlebury et al. (2016) conducted a cross-sectional in Apical ballooning syndrome (Takotsubo/stress cardiomyopathy) (n=53). Apical ballooning syndrome vs. General population (US normative sample) was evaluated on Neuroticism T-score on the NEO-PI-3 (95% CI 45.1 to 50.9, p=0.18). Patients with apical ballooning syndrome did not manifest higher levels of neuroticism compared with the normal population (mean T-score 48.0 vs 50, p=0.18).
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