Design and Characterization of Amlodipine Besylate Transdermal Patches Using Hydroxy Propyl Methyl Cellulose and Ethyl Cellulose Combination

Amlodipine besylate, an antihypertensive hypertension.There are various conventional dosage forms of amlodipine besy impediments, for example, first pass metabolism, edema.Transdermal drug delivery systems have various advantages over conventional dosage forms such as decreased local and systemic side effects, optimized therapy, improved patient compliance, less frequent dosing, economical to the health care providers and the patients.transdermal drug delivery system for amlodipine besylate.and different transdermal patches were prepared by solvent casting method by using pol Methyl Cellulose (HPMC) and Ethyl Cellulose (EC) in different ratios.formulations across cellophane membrane.using buffer PBS 7.4 as receptor medium convergence of hydrophilic polymer in the polymer lattice.This is because of the way fraction of polymer matrix leads to the form the mean diffusion path length of molecules to release into the diffusion medium and hence, to cause higher release rate.The highest cumulative drug permeated was found in formulation proportion 7:3.