Key result
High-fructose diet increases infarct size by ~36% and worsens arrhythmias following ischemia-reperfusion in rats.
Why the study?
The early prediabetic state characterized by hyperinsulinaemia may alter myocardial cell metabolism and decrease cardiac tolerance to ischaemia and reperfusion.
Does a fructose-induced prediabetic state decrease cardiac tolerance to in vivo ischaemia/reperfusion in male Wistar rats?
Population
Male Wistar rats fed a 66% fructose diet for 4 weeks
Comparison
Fructose-fed prediabetic rats vs control rats
Design
Preclinical in vivo study with left coronary artery ligation and reperfusion
Authors
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Prediabetic hyperinsulinemia may impair rat myocardial ischemia tolerance; leaves open relevance to human prediabetes.
Does a fructose-induced prediabetic state decrease cardiac tolerance to in vivo ischaemia/reperfusion in male Wistar rats?
Absolute Event Rate: 56% vs 41.2%
p-value: p=< 0.01
A fructose-induced prediabetic state in rats decreases cardiac tolerance to ischemia/reperfusion, increasing arrhythmia severity and infarct size, potentially due to altered plasma fatty acid distribution.
Morel et al. (2003) studied Prediabetic state and myocardial ischaemia/reperfusion. 66% fructose diet vs. Control diet was evaluated on Size of infarction (p=< 0.01). A 66% fructose diet inducing a prediabetic state significantly increased infarct size (56.0% vs 41.2%; P<0.01) and arrhythmia severity following in vivo ischaemia/reperfusion in rats.
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