Intraendothelial Inclusions in Systemic Lupus Erythematosus

Letters, Comments, and Corrections1 January 1972Intraendothelial Inclusions in Systemic Lupus ErythematosusJOSEPH G. SINKOVICS, M.D., F.A.C.P.JOSEPH G. SINKOVICS, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-76-1-142 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The critical review of intraendothelial inclusions inclusions by Tisher and colleagues (Ann Intern Med 75:537-547, 1971) certainly deserves compliments. In a report to appear soon (1) we agree that the prevalence of these structures in systemic lupus erythematosus (SLE) is highly significant and of great diagnostic value. However, the inclusions occur in lymphoid cells as well (1); thus the term "intraendothelial" should not be applied generally.Two further comments are appropriate. When Tisher and colleagues state that these inclusions "bear little resemblance to any of these known viruses" and give the diameters of myxoviruses and paramyxoviruses as...References1. GYORKEYSINKOVICSMIN FJK: A morphological study on the occurrence and distribution of structures resembling viral nucleocapsids in collagen diseases. Am J Med. In press Google Scholar2. SINKOVICSGYORKEYTHOMA JFG: A rapidly fatal case of systemic lupus erythematosus: structures resembling viral nucleoprotein strands in the kidney and activities of lymphocytes in culture. Texas Rep Biol Med 27:887-908, 1969 MedlineGoogle Scholar3. HAASYUNIS JE: Tubular inclusions of systemic lupus erythematosus. Ultrastructural observations regarding their possible viral nature. Exp Mol Pathol 12:257-263, 1970 CrossrefGoogle Scholar4. GYORKEYMINGYORKEY FKP: Myxovirus-like structures in human collagen diseases (abstract). Arthritis Rheum 12:300, 1969 Google Scholar5. SINKOVICSSYKESSHULLENBERGER JJC: Patterns of growth in cultures deriving from human leukemic sources. Texas Rep Biol Med 25:446-467, 1967 MedlineGoogle Scholar6. BENYESH-MELNICKFERNBACHLEWIS MDR: Studies on human leukemia. I. Spontaneous lymphoblastoid transformation of fibroblastic bone marrow cultures derived from leukemic and nonleukemic children. J Natl Cancer Inst 31:1311-1325, 1963 MedlineGoogle Scholar7. EISINGERFOXDEHARVEN MSE: Virus-like agents from patients with Hodgkin's disease. Nature (Lond) 233:104-108, 1971 CrossrefMedlineGoogle Scholar8. KOPROWSKIBARBANTI-BRODANOKATZ HGM: Interaction between papova-like virus and paramyxovirus in human brain cells: a hypothesis. Nature (Lond) 255:1045-1047, 1970 CrossrefGoogle Scholar9. STEINBERGBARONTALAL ASN: The pathogenesis of autoimmunity in New Zealand mice. I. Induction of antinucleic acid antibodies by polyinosinic polycytidylic acid. Proc Natl Acad Sci USA 63:1102-1107, 1969 CrossrefMedlineGoogle Scholar10. TONIETTIOLDSTONEDIXON GMF: The effect of induced chronic viral infections on the immunologic diseases of New Zealand mice. J Exp Med 132:89-109, 1970 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: JOSEPH G. SINKOVICS, M.D., F.A.C.P.Affiliations: Section of Clinical Tumor Virology and Immunology Department of Medicine The University of Texas at Houston M. D. Anderson Hospital and Tumor Institute Houston, Tex. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byColonic epithelial cells and polymorphonuclear leukocytes in ulcerative colitisLymphocyte InclusionsJAMES G. WHITE, M.D. 1 January 1972Volume 76, Issue 1Page: 142-143KeywordsLupus erythematosusLymphocytes ePublished: 1 December 2008 Issue Published: 1 January 1972 PDF downloadLoading ...