The Excretion of Trypsin Inhibitor in Urine During Normal Pregnancy

The excretion of trypsin inhibitor (T. I.) in the urine of normal non-pregnant women lies between 0 and 10,000 units per 24 hour period. The excretion differs considerably from subject to subject, but remains at a rather constant level in a particular subject (Faarvang, 1958). The hourly rhythm of the excretion of T.I. in urine follows closely that of the 17-ketosteroids and 17-ketogenic steroids, and since corticotrophin, cortisone and hydrocortisone increase the excretion of T. I. in normal subjects, a close relationship exists between the pituitary-adrenal system and the excretion of T. I. (Faarvang, 1957 and 1958).