Key result
Benign cardiac tumors demonstrate excellent long-term survival while malignant tumors are linked to early death.
Why the study?
The prognostic impact of histological subtypes of primary cardiac tumors remains poorly understood due to their rarity.
Observational (n=41)
No
Benign primary cardiac tumors, particularly myxomas, have excellent long-term outcomes after resection, whereas malignant tumors like DLBCL are associated with early mortality.
Answers are grounded in this paper and cite their sources.
Benign primary cardiac tumors confer excellent post-resection survival; observational data leave open whether histology should guide subtype-specific therapies.
Background: Primary cardiac tumors are rare, and the prognostic impact of their histological subtypes remains poorly understood. We assessed the clinical outcomes of benign and malignant tumors using long-term follow-up data from pathologically confirmed cases. Methods and Results: We retrospectively analyzed 42 consecutive patients diagnosed with primary cardiac tumors between 2007 and 2022 at a single center. Among them, 41 patients who underwent surgical resection were followed longitudinally and included in the present study. Clinical features, tumor distribution, and outcomes were assessed by histological type, with particular focus on long-term prognosis. Histological diagnoses were confirmed in each case. Myxomas accounted for 73% (n=30), diffuse large B-cell lymphomas (DLBCLs) for 7% (n=3), and other benign tumors for 20% (n=8) of cases. Myxomas were predominantly located in the left atrium and showed excellent long-term outcomes, with no recurrence or tumor-related deaths over a median follow-up of 12.8 years. In contrast, all patients with DLBCL had right-sided tumors and died within 2 years due to disease progression despite surgery and chemotherapy. Kaplan-Meier analysis showed significant differences (P<0.001) in survival among tumor types, with DLBCL showing uniformly poor outcomes. Conclusions: Benign cardiac tumors had favorable outcomes, with myxomas showing a particularly excellent prognosis. In contrast, malignant tumors were uniformly associated with early death. Histological subtype may be associated with survival.
No takes yet. Share an insight, caveat, or question.
Shiba et al. (2026) conducted an observational in Primary cardiac tumors (n=41). Histological subtype (Malignant vs Benign) vs. Benign tumors was evaluated on Overall survival (p=<0.001). Benign cardiac tumors, particularly myxomas, demonstrated excellent long-term survival, whereas malignant tumors (diffuse large B-cell lymphomas) were uniformly associated with early death (P<0.001).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: