Key result
Catheter-directed tPA successfully resolves a hemodynamically significant saddle PE in a third-trimester pregnant patient.
Why the study?
Pulmonary embolism is a leading cause of maternal death and requires aggressive intervention when associated with cardiovascular collapse in pregnancy.
Case Report (n=1)
Catheter-directed thrombolysis may be a viable aggressive intervention for massive pulmonary embolism during pregnancy when cardiovascular collapse is imminent.
May support use in select pregnant patients with high-risk PE; leaves open prospective evaluation of risks and benefits.
Pulmonary embolism is a leading cause of maternal death in the United States, contributing to the death of approximately 2 women per 100,000 live births each year. Thrombosis during pregnancy traditionally is treated conservatively with unfractionated heparin or low-molecular-weight heparin; however, cardiovascular collapse associated with a large pulmonary embolus may require immediate aggressive intervention to save the mother and fetus. We report the use of catheter infusion thrombolysis in the successful management of a third-trimester pregnant patient with a hemodynamically significant saddle pulmonary embolus.
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Pick et al. (2015) conducted a case report in Massive pulmonary embolism in pregnancy (n=1). Catheter-directed tissue plasminogen activator was evaluated on Successful management. Catheter-directed tissue plasminogen activator was successfully used to manage a hemodynamically significant saddle pulmonary embolus in a third-trimester pregnant patient.
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