Recombinant tissue plasminogen activator was successfully used to treat a massive pulmonary embolism during pregnancy.
Women are at increased risk for DVT and PE during pregnancy for several reasons. Preg-nancy is a thrombophilic state; fibrinogen levels are increased, and during the final trimester thereis a decrease in fibrinolytic activity. In addition, the gravid uterus causes compression and stasis inthelowerextremitiesandpelvicveinsfavoringthrombosis.
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Ahearn et al. (2002) studied this question.
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