Efficacy and clinical outcomes of bone-marrow mononuclear cell therapy in chronic heart failure: a systemic review and meta-analysis

Fig. 1. Prisma flow chart

Fig. 2. Risk of bias

Fig. 3. Risk of bias graph summary

Fig. 4. A Forest plot for the comparisons between BM-MNC versus control group. In which total shown the total number of patient and event shown the performed procedure, 7/60 patients in the BM-MNC group and 7/60 patients in the control group. Risk ratio gives the estimated standardized mean difference and its [RR = 0.99, 95%Cl (0.40,2.49), P = 0.99]. B Funnel plot for morbidity.

Fig. 5. A Forest plot for the comparisons between BM-MNC versus control group. In which total shown the total number of patient and event shown the performed procedure, 6/30 patients in the BM-MNC group and 4/33 patients in the control group. Risk ratio gives the estimated standardized mean difference and its [RR = 1.55, 95%Cl (0.50,4.85), P = 0.45]. B Funnel plot for mortality

Fig. 6. A Forest plot for the comparisons between BM-MNC versus control group. In which total shown the total number of patient and event shown the performed procedure, 22/189 patients in the BM-MNC group and 20/190 patients in the control group. Risk ratio gives the estimated standardized mean difference and its [RR = 1.09, 95%Cl (0.63,1.88) P = 0.75]. B Funnel plot for rehospitalization.

Fig. 7. A Forest plot for the comparisons between BM-MNC versus control group. In which total shown the total number of patient and event shown the performed procedure, 2/43 patients in the BM-MNC group and 4/44 patients in the control group. Risk ratio gives the estimated standardized mean difference and its [RR = 0.59,95% (0.14, 2.46), P = 0.47]. B Funnel plot for MACE based on route of injection

Fig. 8. A Forest plot for the comparisons between BM-MNC versus control group. In which total shown the total number of patient and event shown the performed procedure, 6/30 patients in the BM-MNC group and 4/33 patients in the control group. Risk ratio gives the estimated standardized mean difference and its [RR = 1.55, 95%Cl(0.50,4.85), P = 0.45]. B Funnel plot for hospital based on route of injection

Fig. 9. A Forest plot for the comparisons between BM-MNC versus control group. In which total shown the total number of patient and event shown the performed procedure, 22/189 patients in the BM-MNC group and 20/190 patients in the control group. Risk ratio gives the estimated standardized mean difference and its [RR = 1.09, 95%Cl (0.63,1.88), P = 0.75]. B Funnel plot for death based on route of injection

Fig. 10. A Forest plot for the comparisons between BM-MNC versus control group. In which total shown the total number of patient and event shown the performed procedure, 163 patients in the BM-MNC group and 158 patients in the control group. [MD=−0.73, 95%Cl (−2.14,0.68), P = 0.31]. B Funnel plot for LVEF

Fig. 11. A Forest plot for the comparisons between BM-MNC versus control group. In which total shown the total number of patient and event shown the performed procedure, 132 patients in the BM-MNC group and 126 patients in the control group. [MD = 2.34, 95%Cl (−1.94,6.62), P = 0.28]. B Funnel plot for LVEF after 3 months

Fig. 12. A Forest plot for the comparisons between BM-MNC versus control group. In which total shown the total number of patient and event shown the performed procedure, 126 patients in the BM-MNC group and 120 patients in the control group. [MD = 1.69, 95%Cl (−2.29,5.66), P = 0.41]. B Funnel plot for LVEF after one year.