Key result
Vitamin D supplementation reduces systolic blood pressure by ~5 mmHg vs control in T2D.
Why the study?
The effects of individual micronutrients on blood pressure in patients with type 2 diabetes were not well established.
Do individual micronutrients reduce blood pressure in patients with type 2 diabetes?
Systematic Review (n=723)
Do individual micronutrients reduce blood pressure in patients with type 2 diabetes?
Mean Difference: -4.56 (95% CI -7.65–-1.47)
p-value: p=0.004
Vitamin D and possibly vitamin C supplementation may have beneficial effects on lowering blood pressure in patients with type 2 diabetes.
Supports adjunctive vitamin D for BP control in type 2 diabetes; extends micronutrient evidence in this population.
To investigate the effects of micronutrients on blood pressure (BP) in patients with type 2 diabetes through a systematic review and meta-analysis, randomized clinical trials (RCTs) of the effects of individual micronutrients on BP in patients with type 2 diabetes were searched in the Medline, Embase, Cochrane, and Clinical Trials.gov databases through April 2016. From the 28,164 studies, 11 RCTs (13 interventions, 723 patients, 54% males) with 3 to 52 weeks of follow-up were classified according to the type of micronutrient intervention: sodium (n = 1), vitamin C (n = 2), vitamin D (n = 7), and magnesium (n = 1). The available data enabled us to perform meta-analyses of vitamins C and D. Vitamin C reduced diastolic BP [WMD -2.88 mmHg (95%CI -5.31, -0.46; P = 0.020)] but not systolic BP [WMD -3.93 mmHg (95%CI -14.78, 6.92; P = 0.478)]. Vitamin D caused a reduction of 4.56 mmHg (WMD; 95%CI -7.65, -1.47; P = 0.004) for systolic BP and 2.44 mm Hg (WMD; 95%CI -3.49, -1.39; P < 0.001) for diastolic BP. In conclusion, vitamin D and possibly vitamin C have beneficial effects on BP in patients with type 2 diabetes. These interventions might represent a novel approach to the treatment of hypertension in these patients.
No takes yet. Share an insight, caveat, or question.
Paula et al. (2017) conducted a systematic review in Type 2 diabetes (n=723). Vitamin D supplementation vs. Placebo or control diet was evaluated on Systolic blood pressure (WMD -4.56 mmHg, 95% CI -7.65 to -1.47, p=0.004). Vitamin D supplementation significantly reduced systolic blood pressure by 4.56 mmHg and diastolic blood pressure by 2.44 mmHg compared to control in patients with type 2 diabetes.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: