Key result
Postprandial hyperglycemia linked to worse CFR in patients with T2D.
Why the study?
The adverse effect of postprandial hyperglycaemia on coronary microvascular function and left ventricular diastolic function was investigated.
Observational (n=28)
Effect estimate: β = 0.38
p-value: p=0.048
Postprandial hyperglycemia, marked by 1,5-anhydroglucitol, is independently associated with impaired coronary flow reserve in patients with type 2 diabetes, suggesting a mechanism for coronary microvascular dysfunction.
May link postprandial hyperglycemia to coronary microvascular dysfunction in T2D; hypothesis-generating and requires prospective confirmation.
BACKGROUND: This study investigated whether postprandial hyperglycaemia has an adverse effect on coronary microvascular function and left ventricular diastolic function. METHODS: In all, 28 patients with type 2 diabetes mellitus with no significant stenosis in left anterior descending artery were enrolled. In all subjects, plasma 1,5-anhydroglucitol was measured, and coronary flow reserve in the left anterior descending artery was evaluated using a Doppler wire. Membrane type-1 matrix metalloproteinase expression on circulating peripheral blood mononuclear cells was measured by flow cytometry. Correlation analyses were performed for coronary flow reserve and 1,5-anhydroglucitol, other coronary risk factors, membrane type-1 matrix metalloproteinase and E/e'. RESULTS: Strong correlations were found only between 1,5-anhydroglucitol and coronary flow reserve and membrane type-1 matrix metalloproteinase. On multiple regression analysis, 1,5-anhydroglucitol remained an independent predictor of coronary flow reserve (β = 0.38, p = 0.048). CONCLUSION: Postprandial hyperglycaemia appears to have an adverse effect on coronary microvascular function, suggesting that improvement of postprandial hyperglycaemia may contribute to the improvement of coronary microvascular dysfunction.
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Ikeda et al. (2015) conducted an observational in Type 2 diabetes mellitus (n=28). Postprandial hyperglycaemia (1,5-anhydroglucitol) was evaluated on Coronary flow reserve (β = 0.38, p=0.048). Postprandial hyperglycaemia, assessed by 1,5-anhydroglucitol, was an independent predictor of coronary flow reserve (β = 0.38, p = 0.048) in patients with type 2 diabetes.
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