Long-term type 1 diabetes without coronary artery disease was associated with reduced LV strain (-19.5% vs -21.4%, p<0.05) and lower myocardial blood flow reserve (3.4 vs 5.9, p<0.01) versus controls.
Case-Control (n=46)
Does long-term type 1 diabetes without significant coronary artery disease impair left ventricular function and myocardial blood flow reserve compared to controls?
Long-term type 1 diabetes patients without significant coronary artery disease exhibit impaired left ventricular function and reduced myocardial blood flow reserve, which correlate with advanced glycation end products.
Absolute Event Rate: -19.5% vs -21.4%
p-value: p=<0.05
Our aims were to study left ventricular (LV) function and myocardial blood flow reserve (MBFR) in long-term type 1 diabetes and associations with advanced glycation end products (AGEs). A total of 20 type 1 diabetes patients from the Oslo Study without significant stenosis on coronary angiography were compared with 26 controls. LV systolic and diastolic functions were assessed by two-dimensional strain and the ratio between pulsed Doppler transmitral early (E) velocity and tissue Doppler velocity (E'), respectively. MBFR was evaluated by contrast echocardiography. The AGE methylglyoxal-derived hydroimidazolone was analysed in serum. Glyoxal hydroimidazolone in skin collagen was determined by liquid chromatography-mass spectrometry. Strain was significantly reduced (-19.5% ± 1.9% vs -21.4% ± 3.5%, p < 0.05), and E/E' increased in the diabetes patients compared to controls, 7.3 ± 2 versus 6.0 ± 1.5, p < 0.05. Significant lower MBFR was present in the diabetes patients, 3.4 (2.1, 5.3) versus 5.9 (3.9, 9.6), p < 0.01. Both AGEs correlated significantly with E/E'. The impaired LV function with correlation to AGEs in concert with reduced MBFR in diabetics without coronary artery disease may indicate possible mechanisms for diabetic cardiomyopathy.
Sveen et al. (Fri,) conducted a case-control in Type 1 diabetes (n=46). Long-term type 1 diabetes vs. Controls was evaluated on Left ventricular systolic function assessed by two-dimensional strain (p=<0.05). Long-term type 1 diabetes without coronary artery disease was associated with reduced LV strain (-19.5% vs -21.4%, p<0.05) and lower myocardial blood flow reserve (3.4 vs 5.9, p<0.01) versus controls.