Key result
In patients with type 1 diabetes, LV systolic tissue velocity was significantly inversely correlated with coronary atherosclerotic burden (r=0.53, p<0.01) and long-term HbA1c (r=0.46, p<0.05).
Why the study?
Are poor glycaemic control, coronary atherosclerosis, and advanced glycation endproducts associated with LV systolic impairment in patients with type 1 diabetes?
Population
26 patients with type 1 diabetes (mean duration 32+/-5 years) and 16 age-matched controls
Design
Cross-sectional
Authors
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Associates long-term hyperglycemia and coronary burden with LV systolic impairment in type 1 diabetes; hypothesis-generating, prospective studies needed before clinical adoption.
Cross-Sectional (n=42)
Are poor glycaemic control, coronary atherosclerosis, and advanced glycation endproducts associated with LV systolic impairment in patients with type 1 diabetes?
Effect estimate: r=0.53
p-value: p=<0.01
Steine et al. (2007) conducted a cross-sectional in Type 1 diabetes and asymptomatic coronary heart disease (n=42). Coronary atherosclerosis, glycaemic control, and advanced glycation endproducts vs. Age-matched controls was evaluated on Correlation of systolic tissue velocity with coronary atherosclerotic burden (CAB) (r=0.53, p=<0.01). In patients with type 1 diabetes, LV systolic tissue velocity was significantly inversely correlated with coronary atherosclerotic burden (r=0.53, p<0.01) and long-term HbA1c (r=0.46, p<0.05).
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