Key result
In patients with heart failure, diabetes was associated with higher tissue advanced glycation end products (2.8 vs 2.3 a.u.; P<0.001) and lower aerobic capacity (17.4 vs 21.7 mL/min/kg; P=0.001).
Cross-Sectional (n=205)
Absolute Event Rate: 2.8% vs 2.3%
p-value: p=<0.001
In heart failure patients, higher tissue advanced glycation end products are associated with worse diastolic function and lower aerobic exercise capacity, which may explain the poorer exercise capacity observed in those with diabetes.
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Tissue AGEs may identify diabetic HF patients with worse diastolic function and exercise tolerance; leaves open whether AGE-targeted interventions improve outcomes.
Willemsen et al. (2010) conducted a cross-sectional in Heart failure (n=205). Diabetes vs. Non-diabetics was evaluated on Tissue AGEs (skin autofluorescence) (p=<0.001). In patients with heart failure, diabetes was associated with higher tissue advanced glycation end products (2.8 vs 2.3 a.u.; P<0.001) and lower aerobic capacity (17.4 vs 21.7 mL/min/kg; P=0.001).
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