What question did this study set out to answer?

To determine whether age-related diastolic dysfunction correlates with altered myocardial histological structure and elevated plasma advanced glycation end-product (AGE) levels in humans.

November 26, 2012PLoS ONEOpen Access

Diastolic Dysfunction of Aging Is Independent of Myocardial Structure but Associated with Plasma Advanced Glycation End-Product Levels

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Why the study?

Is diastolic dysfunction of aging associated with altered myocardial structure and plasma AGE levels in men undergoing CABG?

Population

26 men aged 43-78 years undergoing coronary artery bypass graft surgery who had transthoracic…

Design

Cross-sectional

Authors

DCDuncan J. CampbellHeart Failure & Transplant JSJ. SomaratneThe University of Adelaide AJAlicia J. JenkinsGeneral / Preventive / Lipids

Discussion

Member takes

Implication

Plasma CML links to diastolic indices but not structure in aging CABG patients; hypothesis-generating, should not change practice without prospective data.

Key Points

To determine whether age-related diastolic dysfunction correlates with altered myocardial histological structure and elevated plasma advanced glycation end-product (AGE) levels in humans.
Analyzed non-ischemic left ventricular myocardial biopsies for total, interstitial, and perivascular fibrosis, collagens I and III, AGE receptor (RAGE), and microvascular dimensions in N=26 men aged 43–78 years undergoing coronary artery bypass graft surgery.
Assessed cardiac diastolic function via preoperative transthoracic echocardiography and measured circulating levels of the AGEs N(ε)-(carboxymethyl)lysine (CML) and low molecular weight fluorophores (LMWFs).
Age correlated significantly with echocardiographic diastolic dysfunction, including higher mitral A wave velocity (r = 0.50, P = 0.02), lower E/A ratio (r = 0.64, P = 0.001), longer deceleration time (r = 0.42, P = 0.03), and lower septal e' velocity (r = 0.55, P = 0.008).
Echocardiographic diastolic indices did not correlate with myocardial fibrosis, collagen content, cardiomyocyte width, or vascular geometry, but plasma CML correlated with E/A ratio (r = 0.44, P = 0.04) and e' (r = 0.51, P = 0.02).
Mitral E/A ratio remained associated with plasma LMWF in all patients (P = 0.04), and septal e' remained correlated with plasma CML in non-diabetic patients (P = 0.007) when controlling for age.

Structured PICO

Is diastolic dysfunction of aging associated with altered myocardial structure and plasma AGE levels in men undergoing CABG?

Population

26 men aged 43-78 years undergoing coronary artery bypass graft surgery who had transthoracic echocardiography before surgery, with no previous cardiac surgery, myocardial infarction, atrial fibrillation, or heart failure.

Outcome

Correlation between echocardiographic indices of diastolic dysfunction (mitral E/A ratio, mitral septal e') and myocardial structure (fibrosis, collagen, CML, RAGE, cardiomyocyte width, capillary length density) as well as plasma AGE levels (CML, LMWFs).surrogate

Diastolic dysfunction in aging is associated with plasma advanced glycation end-product levels rather than structural myocardial changes like fibrosis.

Cite This Study

Campbell et al. (2012) studied this question.

synapsesocial.com/papers/6a72b5f0a528af2d65c4822b https://doi.org/10.1371/journal.pone.0049813

Topics

Coronary artery disease Echocardiography

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Implication

Plasma CML links to diastolic indices but not structure in aging CABG patients; hypothesis-generating, should not change practice without prospective data.

Diastolic Dysfunction of Aging Is Independent of Myocardial Structure but Associated with Plasma Advanced Glycation End-Product Levels

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Diastolic Dysfunction of Aging Is Independent of Myocardial Structure but Associated with Plasma Advanced Glycation End-Product Levels

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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Topics

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