Key result
Life-long congenital cyclo-oxygenase deficiency fails to protect against progressive vascular disease and generalized atherosclerosis.
Why the study?
The protective effect of congenital cyclo-oxygenase deficiency against progressive vascular disease was unclear.
Case Report (n=1)
This case suggests that life-long cyclo-oxygenase deficiency does not protect against progressive vascular disease, implying chronic high-dose aspirin may not prevent arterial disorders.
Answers are grounded in this paper and cite their sources.
Single case does not support COX inhibition preventing atherosclerosis; leaves open effects in broader populations.
The case of a 52-year-old woman with congenital cyclo-oxygenase deficiency, signs of generalized atherosclerosis and a moderate bleeding tendency is reported. Secondary platelet aggregation was absent. Platelet aggregation induced by arachidonic acid failed totally while that induced by calcium ionophore was normal. No malondialdehyde formation could be detected in her platelet-rich-plasma. The life-long deficiency of cyclo-oxygenase had not protected her from progressive vascular disease. This case suggests that the chronic intake of large doses of aspirin cannot prevent arterial disorders.
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Boda et al. (1981) conducted a case report in Congenital cyclo-oxygenase deficiency and generalized atherosclerosis (n=1). Congenital cyclo-oxygenase deficiency was evaluated on Progressive vascular disease. Life-long congenital cyclo-oxygenase deficiency did not protect a 52-year-old woman from developing progressive vascular disease and generalized atherosclerosis.
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