Key result
Dystrophic mice exhibit fewer atrial granules and reduced Golgi area, suggesting inhibited ANP synthesis.
Why the study?
The alteration of atrial granularity and myocardial lesions in dystrophic mice and their impact on atrial natriuretic polypeptide synthesis were not well characterized.
Population
Dystrophic and non-dystrophic mice atria
Comparison
Dystrophic mice vs non-dystrophic controls
Design
Light and electron microscopy observational study
Authors
Loading...
May indicate atrial pathology in muscular dystrophy; leaves open translational relevance to human cardiomyopathy.
Nomura et al. (1987) studied Muscular dystrophy. Dystrophy vs. Non-dystrophic mice was evaluated on Number of granules per unit area and relative area occupied by Golgi fields. Dystrophic mice exhibited significantly fewer atrial granules and reduced Golgi field area compared to non-dystrophic controls, suggesting inhibited atrial natriuretic polypeptide synthesis.
Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context: