Key result
Voltage-clamp analysis of mouse neuroblastoma cells reveals four distinct ionic membrane currents.
Why the study?
Ionic membrane currents in a voltage-clamped neuronal cell line derived from mouse C1300 neuroblastoma were examined to characterize their components and properties.
The molecular structures of sodium and potassium channels in mammalian neuroblastoma cells are functionally similar to those in non-mammalian preparations.
Authors
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Supports functional similarity of Na/K channels in mammalian cells; leaves open translation to human cardiovascular electrophysiology.
Moolenaar et al. (1977) studied Mouse C1300 neuroblastoma cells. Voltage clamp examination was evaluated on Ionic membrane currents. Examination of ionic membrane currents in a voltage-clamped mouse C1300 neuroblastoma cell line disclosed four kinetically different components: sodium, potassium, calcium, and leakage current.
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