Key result
Mechanical overload and aging in rats alter cardiac myosin heavy-chain structures compared to young hearts.
Why the study?
Mechanical overloading and ageing may induce synthesis of new cardiac myosin heavy-chain isoforms, but their presence and differences were not fully characterized.
Population
Young and older rats with normal and mechanically overloaded hearts
Comparison
Mechanically overloaded hearts and ageing vs normal hearts of young rats
Design
Preclinical biochemical analysis of myosin heavy-chain peptides
Authors
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Rat model data on myosin isozymes warrant no clinical change; leaves open translation to human cardiac overload or aging.
Mechanical overloading and aging induce the synthesis of a distinct cardiac myosin heavy chain isozyme in rat models.
Klotz et al. (1981) studied Mechanical heart overloading and ageing. Mechanical heart overloading and ageing vs. Normal hearts of young rats was evaluated on Peptide patterns of cardiac myosin heavy chains. Mechanical overloading and ageing in rats stimulate the synthesis of cardiac myosin isozymes with heavy-chain primary structures different from those in normal young rat hearts.
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