Key result
Low preoperative Karnofsky Performance Status linked to ~32-fold higher risk of adverse perioperative craniotomy outcomes.
Why the study?
It is important to assess preoperative general and functional status to predict perioperative outcomes in patients undergoing brain tumor surgery.
Do preoperative functional status scores (KPS, mRS) predict adverse perioperative outcomes in patients undergoing elective craniotomy for brain tumors?
Population
122 patients undergoing elective craniotomy for brain tumor surgery
Comparison
Preoperative risk factors including KPS score, mRS grade, GCS score, age, gender, and tumor-related factors
Design
Prospective cohort study
Follow-up
Perioperative period
Authors
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Low KPS may flag higher perioperative risk in elective craniotomy; leaves open prospective validation before guiding practice.
Cohort (n=122)
No
Do preoperative functional status scores (KPS, mRS) predict adverse perioperative outcomes in patients undergoing elective craniotomy for brain tumors?
Odds Ratio: 32.333 (95% CI 3.67–284.872)
p-value: p=<0.001
Preoperative functional status, specifically low KPS and high mRS scores, are important predictors of adverse perioperative outcomes in patients undergoing brain tumor surgery.
Kafle et al. (2023) conducted a cohort in Brain tumors (n=122). Low preoperative Karnofsky Performance Status (KPS <70) vs. KPS >70 was evaluated on Adverse perioperative outcomes (morbidity and mortality) (OR 32.333, 95% CI 3.670-284.872, p=<0.001). Low preoperative Karnofsky Performance Status (<70) was significantly associated with adverse perioperative outcomes (OR 32.33) in patients undergoing elective craniotomy for brain tumors.
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