Key result
CONUT-defined malnutrition linked to ~32% greater MACE risk after carotid artery stenting.
Why the study?
Malnutrition is associated with poor clinical outcomes in many diseases, but its prognostic value in patients undergoing carotid artery stenting was unclear.
Does malnutrition assessed by the CONUT score predict major adverse cardiac events in patients undergoing carotid artery stenting?
Cohort (n=170)
Does malnutrition assessed by the CONUT score predict major adverse cardiac events in patients undergoing carotid artery stenting?
Odds Ratio: 1.318 (95% CI 1.017–1.881)
p-value: p=0.039
Malnutrition, as assessed by a CONUT score ≥2, is an independent predictor of long-term major adverse cardiac events and mortality in patients undergoing carotid artery stenting.
Objective: Malnutrition is associated with poor clinical outcomes in many diseases. The Controlling Nutritional Status (CONUT) is an objective index used for evaluating nutritional status of hospitalized patients. The aim of this study was to investigate the relationship between malnutrition assessed by CONUT score and the prognosis in patients undergoing carotid artery stenting (CAS). Methods: The study included 170 patients who underwent CAS due to symptomatic or asymptomatic severe carotid artery stenosis. Median follow-up period was 50 (interquartile range [IQR], 41-60) months. Patients were divided into two groups according to the CONUT score: (i) normal nutrition (<2) and (ii) malnutrition (≥2). Primary endpoint was accepted as MACE (major adverse cardiac events) including all-cause death and ischemic stroke. Results:The prevalence of MACE was significantly higher in the malnutrition group (p=0.001). Kaplan Meier analysis showed lower survival rates in the malnutrition group (log rank = 9.36, p=0.002; Figure 4). In multivariate logistic regression analysis, age and CONUT score were independent predictors of all-cause death and stroke after adjustment for confounding factors, respectively, (OR: 1.058, 95% CI: 1.013-1.105, p=0.011, OR: 1.318, 95% CI: 1.017-1.881, p=0.039). Conclusion: Higher CONUT scores were associated with adverse outcomes in patients with CAS. Malnutrition assessed by the CONUT score may provide valuable prognostic information in patients with CAS.
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Demir et al. (2021) conducted a cohort in Severe carotid artery stenosis (n=170). Malnutrition (CONUT score ≥2) vs. Normal nutrition (CONUT score <2) was evaluated on MACE (major adverse cardiac events) including all-cause death and ischemic stroke (OR 1.318, 95% CI 1.017-1.881, p=0.039). Malnutrition assessed by CONUT score was independently associated with increased risk of all-cause death and stroke after carotid artery stenting (OR 1.318; 95% CI 1.017-1.881; p=0.039).
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