Key result
Neomycin and carbodiimide cross-linking improves bioprosthetic valve biomechanics and reduces calcification without formaldehyde storage.
Why the study?
Glutaraldehyde cross-linking of bioprosthetic heart valves does not stabilize glycosaminoglycans, leading to their loss during preparation, implantation, fatigue, and storage.
Does neomycin and carbodiimide crosslinking improve durability and reduce calcification in bioprosthetic heart valves?
Population
Porcine aortic valves and rat subdermal implantation model
Comparison
Neomycin and carbodiimide cross-linking vs glutaraldehyde cross-linking
Design
Preclinical experimental study
Authors
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May support preclinical refinement of valve preservation; leaves open whether benefits translate to human durability.
Does neomycin and carbodiimide crosslinking improve durability and reduce calcification in bioprosthetic heart valves?
Neomycin and carbodiimide crosslinking, combined with formaldehyde-free storage, may offer a more durable alternative to glutaraldehyde for bioprosthetic heart valves by improving GAG retention and reducing calcification.
Leong et al. (2011) studied Bioprosthetic heart valve durability and calcification. Neomycin and carbodiimide cross-linking vs. Glutaraldehyde cross-linking was evaluated on Glycosaminoglycan retention, biomechanical properties, and calcification. Neomycin and carbodiimide cross-linking of bioprosthetic heart valves improved glycosaminoglycan retention and biomechanical properties, and reduced calcification when formaldehyde storage was removed.
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