Why the study?
Are extracellular matrix degrading enzymes active in glutaraldehyde-fixed porcine aortic bioprosthetic heart valves?
Population
Unimplanted, glutaraldehyde-fixed porcine aortic cusp and wall tissues, and fresh tissues
Comparison
Glutaraldehyde fixation vs Fresh porcine aortic tissues
Design
Preclinical
Authors
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Persistent collagenolysis may promote bioprosthetic degeneration; leaves open enzyme inhibition to extend durability in clinical valves.
Are extracellular matrix degrading enzymes active in glutaraldehyde-fixed porcine aortic bioprosthetic heart valves?
Glutaraldehyde-fixed porcine bioprosthetic heart valves retain active matrix-degrading enzymes, challenging the assumption that they are metabolically inert and suggesting a mechanism for biologic degeneration.
Simionescu et al. (2003) studied this question.
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