Population
Glutaraldehyde fixed porcine aortic valve bioprostheses (in vitro model)
Comparison
In vitro accelerated fatigue vs Control (uncycled cusps)
Design
Preclinical
Authors
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Fatigue-induced matrix damage may contribute to bioprosthetic valve failure; leaves open in vivo strategies to preserve durability.
In vitro accelerated fatigue of bioprosthetic heart valves causes progressive damage to type I collagen and loss of glycosaminoglycans, contributing to material degeneration.
Vyavahare et al. (1999) studied this question.
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