Key result
Accelerated durability testing up to 200 million cycles significantly decreased the bending stiffness of both radial and circumferential porcine bioprosthetic aortic heart valve specimens.
Why the study?
Does mechanical fatigue decrease the bending stiffness of porcine bioprosthetic heart valves?
Population
Porcine bioprosthetic aortic heart valve specimens (10 circumferential and 15 radial specimens)
Comparison
Accelerated durability testing vs Unfatigued specimens (0 cycles)
Design
Preclinical
Authors
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May inform bioprosthetic valve durability testing; leaves open translation to clinical calcification and failure.
Does mechanical fatigue decrease the bending stiffness of porcine bioprosthetic heart valves?
Mechanical fatigue significantly decreases the bending stiffness of porcine bioprosthetic heart valves, particularly in the fibrosa layer, which may contribute to valve failure.
Gloeckner et al. (1999) studied Porcine bioprosthetic aortic heart valves (n=25). Accelerated durability testing (mechanical fatigue) vs. 0 cycles (baseline) was evaluated on Bending stiffness (flexural rigidity). Accelerated durability testing up to 200 million cycles significantly decreased the bending stiffness of both radial and circumferential porcine bioprosthetic aortic heart valve specimens.
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