Key result
Explanted porcine valves primarily failed due to heavy calcification and adjacent leaflet tears causing 30-70% regurgitation, while pericardial valves mostly failed from tears at the frame edge.
Why the study?
What are the mechanisms of failure and hydrodynamic function of explanted pericardial and porcine bioprosthetic valves?
Population
66 explanted pericardial and porcine bioprosthetic valves
Design
Other
Authors
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Distinct failure modes may guide material-specific monitoring; leaves open whether design changes can alter explant outcomes.
Observational (n=66)
What are the mechanisms of failure and hydrodynamic function of explanted pericardial and porcine bioprosthetic valves?
Porcine and pericardial bioprosthetic valves exhibit distinct mechanisms of failure, with porcine valves predominantly failing from calcification-induced tears and pericardial valves from frame-edge tears without calcification.
Fisher et al. (1989) conducted an observational in Explanted cardiac bioprostheses (n=66). Pericardial and porcine bioprosthetic valves was evaluated on Mechanisms of failure and hydrodynamic function. Explanted porcine valves primarily failed due to heavy calcification and adjacent leaflet tears causing 30-70% regurgitation, while pericardial valves mostly failed from tears at the frame edge.
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