Why the study?
Does cyclic tensile loading cause collagen degradation and mechanical changes in glutaraldehyde treated bovine pericardium?
Population
Glutaraldehyde treated bovine pericardium (GLBP) specimens
Comparison
Cyclic tensile loading at 30 Hz to a maximum… vs Baseline/unloaded tissue dimensions
Design
Preclinical
Follow-up
65 x 10^6 cycles
Authors
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May link cyclic loading to collagen changes in pericardial valves; leaves open role in noncalcific degeneration.
Does cyclic tensile loading cause collagen degradation and mechanical changes in glutaraldehyde treated bovine pericardium?
Cyclic mechanical loading of glutaraldehyde-treated bovine pericardium leads to immediate collagen deterioration, fiber straightening, and reorientation, highlighting mechanisms of noncalcific tissue degeneration in bioprosthetic heart valves.
Sun et al. (2004) studied this question.
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