September 1, 1996ASAIO Journal
Biochemical Pathways of Tissue Degeneration in Bioprosthetic Cardiac Valves; The Role of Matrix Metalloproteinases
Key result
Tissue degeneration in explanted bioprosthetic heart valves was associated with increased levels of MMP-9, high beta-glucuronidase, and constant levels of active collagenase and MMP-2.
Authors
Discussion
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Implication
No immediate clinical implications for valve selection or surveillance; leaves open MMP-9 as therapeutic target.
Study Design
Type
Observational (n=28)
PICO
P
Population
28 pericardial derived bioprosthetic heart valves explanted at surgery to study tissue degeneration.
E
Exposure / Comparator
Matrix metalloproteinases (MMPs)
O
Primary Outcome
Biochemical features associated with tissue degeneration and bioprosthetic heart valve failure
Cite This Study
Simionescu et al. (1996) conducted an observational in Bioprosthetic heart valve degeneration (n=28). Matrix metalloproteinases (MMPs) was evaluated on Biochemical features associated with tissue degeneration and bioprosthetic heart valve failure. Tissue degeneration in explanted bioprosthetic heart valves was associated with increased levels of MMP-9, high beta-glucuronidase, and constant levels of active collagenase and MMP-2.