September 1, 1996ASAIO Journal

Complement Activation Is Involved in the Structural Deterioration of Bovine Pericardial Bioprosthetic Heart Valves

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Population

28 clinically failed bioprosthetic heart valves explanted for clinical dysfunction after 69-170 months.

Design

Preclinical

Follow-up

69-170 months (time to explant)

Authors

MMM MoczarUniversité Claude Bernard Lyon 1 LLLaure LecerfInserm MGMaryvonne Ginat

Discussion

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Implication

May implicate immune pathways in bioprosthetic degeneration; hypothesis-generating for human valve durability research.

Structured PICO

Population

28 clinically failed bioprosthetic heart valves (22 Mitroflow, 3 Hancock, 2 Ionescu-Shiley, 1 Sorin) explanted for clinical dysfunction after 69-170 months.

Intervention

Pathological and immunohistochemical analysis of non-calcific deterioration of the prosthetic matrix using labeled antibodies and immunoenzymic assays.

Outcome

Presence and localization of plasma proteins (IgG, complement proteins C1q, C3, C4), fibrin, macrophages, and neutrophil granulocyte elastase in the bioprosthetic matrix.surrogate

Complement activation triggered by IgG aggregates contributes to the structural deterioration and breakdown of the macromolecular matrix in bovine pericardial bioprosthetic heart valves.

Cite This Study

Moczar et al. (1996) studied this question.

synapsesocial.com/papers/6a72ee5ec4285d068c154ac5 https://doi.org/10.1097/00002480-199609000-00015

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Complement Activation Is Involved in the Structural Deterioration of Bovine Pericardial Bioprosthetic Heart Valves

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Complement Activation Is Involved in the Structural Deterioration of Bovine Pericardial Bioprosthetic Heart Valves

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider