Why the study?
Bioprosthetic heart valve lifespan is limited by structural valve degeneration, but proteases in xenogeneic tissue of bioprosthetic heart valves remain poorly studied.
Design
Ex vivo screening analysis using dot blot assay
Authors
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Hypothesis-generating for SVD mechanisms in BHVs; leaves open targeted therapies pending validation.
The detection of an imbalance between matrix metalloproteinases and their inhibitors in degenerated bioprosthetic heart valves suggests a mechanism for structural valve degeneration.
Kostyunin et al. (2022) studied this question.
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