Why the study?
Factors responsible for structural valve degeneration in bioprosthetic heart valves fixed with alternative next-generation chemicals, such as ethylene glycol diglycidyl ether, remain largely unknown.
What are the mechanisms driving structural valve degeneration in ethylene glycol diglycidyl ether-treated bioprosthetic heart valves compared to calcified native aortic valves?
Comparison
Failing ethylene glycol diglycidyl ether-treated BHVs vs calcified native AVs
Design
Comparative translational tissue study
Authors
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Implicates neutrophil proteases in BHV degeneration; leaves open whether targeting them improves durability in patients.
What are the mechanisms driving structural valve degeneration in ethylene glycol diglycidyl ether-treated bioprosthetic heart valves compared to calcified native aortic valves?
Neutrophil- and plasma-derived proteases are major contributors to structural valve degeneration in ethylene glycol diglycidyl ether-treated bioprosthetic heart valves.
Kostyunin et al. (2022) studied this question.
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