Why the study?
Bioprosthetic heart valve lifespan is limited by structural degeneration via proteolytic degradation, but proteases within xenogeneic bioprosthetic heart valve tissue remain poorly studied.
Comparison
Explanted bioprosthetic heart valves vs explanted calcific aortic valves
Design
Dot blot screening analysis
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Further protease characterization in BHVs is needed; leaves open their role in structural degeneration.
Key points are not available for this paper at this time.
A 2022 study studied this question.
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