Key result
AAV-1-mediated gene transfer into human skeletal muscle results in the activation of capsid-specific T cells.
Why the study?
Does AAV-1-mediated gene transfer into human skeletal muscle result in activation of capsid-specific T cells?
Does AAV-1-mediated gene transfer into human skeletal muscle result in activation of capsid-specific T cells?
Highlights that AAV-1 gene delivery to human skeletal muscle triggers an immune response via capsid-specific T cell activation.
AAV-1 is one of the most promising vectors for gene delivery to skeletal muscle. In this issue of Blood, Mingozzi and colleagues now demonstrate that AAV-1-mediated gene transfer into human skeletal muscle results in activation of capsid-specific T cells.
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Thierry VandenDriessche (2009) studied this question. AAV-1-mediated gene transfer into human skeletal muscle results in the activation of capsid-specific T cells.
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