Key result
lncRNA MORT overexpression inhibits bladder cancer cell invasion, migration, and proliferation by downregulating miR-146a-5p.
Why the study?
lncRNA MORT is downregulated in bladder cancer, but its function and regulatory role in this disease are unknown.
lncRNA MORT acts as a tumor suppressor in bladder cancer by downregulating miR-146a-5p, inhibiting cancer cell invasion, migration, and proliferation.
Supports MORT as tumor suppressor in bladder cancer models; hypothesis-generating and leaves open clinical translation.
BACKGROUND: Long noncoding RNAs (lncRNAs) are involved in the progression of various cancers. lncRNA MORT is downregulated in bladder cancer, while its function in this disease is unknown. METHODS: lncRNA MORT and miR-146a-5p expression in 56 bladder cancer patients was detected by RT-qPCR. Correlations between MORT and miR-146a-5p were analyzed by Pearson's correlation coefficient. CCK-8 and flow transwell assays were applied to examine the behavioral changes in HT-1197 and HT-1376. RESULTS: We found that miR-146a-5p was upregulated, while lncRNA MORT was downregulated in bladder cancer. miR-146a-5p and MORT were inversely and significantly correlated in tumor tissues. Overexpression of miR-146a-5p promoted, while overexpression of lncRNA MORT inhibited the invasion, migration, and proliferation of cells of bladder cancer cell lines. In addition, overexpression of lncRNA MORT inhibited miR-146a-5p; miR-146a-5p overexpression failed to significantly affect lncRNA MORT expression but attenuated its inhibitory effects on cancer cell behaviors. CONCLUSION: lncRNA MORT may regulate bladder cancer cell behaviors by downregulating miR-146a-5p.
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Wang et al. (2020) studied Bladder cancer (n=56). lncRNA MORT expression was evaluated on Correlation between MORT and miR-146a-5p expression and effects on cell invasion, migration, and proliferation. lncRNA MORT was downregulated in bladder cancer, and its overexpression inhibited cancer cell invasion, migration, and proliferation by downregulating miR-146a-5p.
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