Key result
LncRNA MIR31HG expression was significantly decreased in bladder cancer tissues compared with adjacent noncancerous tissues (P < 0.05) and negatively associated with TNM stage (P = 0.010).
Observational (n=55)
p-value: p=<0.05
MIR31HG expression is decreased in bladder cancer and negatively associated with TNM stage, suggesting a potential role as a tumor suppressor.
May inform prognostic stratification in bladder cancer; leaves open clinical utility pending prospective validation.
OBJECTIVE: In this study, we examined the relationships between the expression level of long non-coding RNA MIR31HG in bladder cancer and the clinical characteristics. METHODS: A total of 55 tissue samples from patients with bladder cancer were collected, and the lncRNA MIR31HG levels in cancer, paired non-cancer tissues and BC cell lines were detected by real-time quantitative RT-PCR (qRT-PCR). The relationships between MIR31HG level and the clinical characteristics were evaluated. RESULTS: MIR31HG expression was remarkably decreased in bladder cancer tissues compared with adjacent noncancerous tissues (P < 0.05). MIR31HG expression was also significantly down-regulated in four bladder cancer cell lines (P < 0.001). Clinicopathologic analysis revealed that MIR31HG expression was negatively associated with TNM stage (P = 0.010), but not with other clinicopathological characteristics. CONCLUSIONS: These findings revealed that MIR31HG may function as a cancer-suppressor gene to participate in the bladder cancer carcinogenesis and development.
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He et al. (2016) conducted an observational in Bladder cancer (n=55). LncRNA MIR31HG expression vs. Adjacent noncancerous tissues was evaluated on MIR31HG expression level (p=<0.05). LncRNA MIR31HG expression was significantly decreased in bladder cancer tissues compared with adjacent noncancerous tissues (P < 0.05) and negatively associated with TNM stage (P = 0.010).
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