Key result
Longer CT report to tPA time is strongly linked to increased door-to-needle time.
Why the study?
The benefit of tPA in acute ischemic stroke is time dependent, but door-to-needle times in community hospitals often exceed recommended targets and causes of delay need identification.
What work elements are associated with increased door-to-needle time for tPA administration in acute ischemic stroke?
Population
100 patients with acute ischemic stroke receiving tPA at a 574-bed community hospital
Comparison
Time segments from hospital arrival to tPA administration analyzed for delay
Design
Retrospective medical record review with linear regression analysis
Authors
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Identifies a potential workflow target in community stroke care; leaves open whether interventions shorten door-to-needle times.
Observational (n=100)
No
What work elements are associated with increased door-to-needle time for tPA administration in acute ischemic stroke?
Effect estimate: Pearson coefficient 0.868
p-value: p=<.001
The time interval from CT report to tPA administration is a major driver of delayed door-to-needle times in community hospitals, representing a key target for quality improvement.
Pitre et al. (2020) conducted an observational in acute ischemic stroke (n=100). Time segments in acute stroke care (e.g., CT report to tPA administration) was evaluated on Factors associated with increased door-to-needle (DTN) time (Pearson coefficient 0.868, p=<.001). The time interval from CT report to tPA administration was strongly associated with increased door-to-needle time (Pearson coefficient 0.868, P < .001).
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