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September 18, 2026EP EuropaceOpen Access

Flecainide Reduces Exercise-Induced Arrhythmic Burden in PKP2-Related Arrhythmogenic Cardiomyopathy

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Why the study?

Does flecainide reduce exercise-induced arrhythmic burden in patients with PKP2-related arrhythmogenic cardiomyopathy?

Population

Patients with PKP2-Related Arrhythmogenic Cardiomyopathy

Key result

Flecainide reduces exercise-induced arrhythmic burden in patients with PKP2-related arrhythmogenic cardiomyopathy.

Authors

MCMatteo CastrichiniRGRamin GarmanyMAMichael J. Ackerman

Discussion

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Overview

May support flecainide consideration for exercise-triggered arrhythmias in PKP2-ACM; leaves open need for randomized confirmation.

Key Points

  • To determine whether flecainide suppresses exercise-induced ventricular arrhythmias in individuals with PKP2-associated arrhythmogenic cardiomyopathy.
  • Evaluated arrhythmia burden during exercise stress in patients carrying pathogenic PKP2 variants treated with flecainide therapy.
  • Flecainide therapy reduced the frequency and severity of exercise-triggered ventricular arrhythmias in PKP2-related arrhythmogenic cardiomyopathy.

Structured PICO

Does flecainide reduce exercise-induced arrhythmic burden in patients with PKP2-related arrhythmogenic cardiomyopathy?

P
Population
Patients with PKP2-Related Arrhythmogenic Cardiomyopathy
I
Intervention
Flecainide
O
Outcome
Exercise-Induced Arrhythmic Burden

Flecainide may reduce exercise-induced arrhythmic burden in patients with PKP2-related arrhythmogenic cardiomyopathy.

Cite This Study

Castrichini et al. (2026) studied this question. Flecainide reduces exercise-induced arrhythmic burden in patients with PKP2-related arrhythmogenic cardiomyopathy.

synapsesocial.com/papers/6aacf5ed0c46fbdff987dd30https://doi.org/10.1093/europace/euag260
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