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September 18, 2026Heart Rhythm

cBIN1 Gene Therapy Restores Ventricular Synchrony in a Pre-Clinical Model of Ischemic Heart Failure

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Authors

KYKyoichiro YazakiUniversity of UtahMCM. Sofia Ruiz CastilloUniversity of UtahMKMuhammad S. KhanUniversity of Utah

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Overview

Preclinical study demonstrates cBIN1 gene therapy restores ventricular synchrony in ischemic heart failure, suggesting a potential targeted molecular intervention for cardiac dyssynchrony.

Key Points

  • To evaluate the efficacy of targeted cBIN1 gene therapy in restoring ventricular synchrony and cardiac function in a preclinical model of ischemic heart failure.
  • Targeted delivery of cBIN1 gene therapy in a preclinical animal model of ischemic heart failure.
  • Electrophysiological and mechanical assessment of ventricular synchrony and overall cardiac functional recovery.
  • cBIN1 gene therapy significantly improved ventricular electrical and mechanical synchrony.
  • Therapeutic restoration of coordinated ventricular wall motion prevented progressive cardiac dysfunction.

Cite This Study

Yazaki et al. (2026) studied this question.

synapsesocial.com/papers/6aacf6940c46fbdff987ddb1https://doi.org/10.1016/j.hrthm.2026.09.008
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