Key result
Higher brachial-ankle pulse wave velocity is linked to abnormal myocardial work components.
Why the study?
Data regarding the influence of arterial stiffness on myocardial work assessed by non-invasive left ventricular pressure-strain are scarce.
Is brachial-ankle pulse wave velocity associated with myocardial work in non-hypertensive and hypertensive patients with preserved left ventricular ejection fraction?
Cross-Sectional (n=208)
Is brachial-ankle pulse wave velocity associated with myocardial work in non-hypertensive and hypertensive patients with preserved left ventricular ejection fraction?
Effect estimate: AUC 0.653 to 0.725
p-value: p=< 0.05
Increased arterial stiffness, as measured by brachial-ankle pulse wave velocity, is significantly associated with altered myocardial work parameters in individuals with preserved ejection fraction.
Should not change practice in preserved EF; hypothesis-generating for arterial stiffness effects on myocardial work.
Objective Data regarding the influence of arterial stiffness on myocardial work (MW) has been scarce. This study was performed to investigate the association between brachial-ankle pulse wave velocity (baPWV) and MW by non-invasive left ventricular pressure–strain in a population of non-hypertensive and hypertensive individuals. Methods Two hundred and eight participants (104 hypertensive and 104 non-hypertensive individuals) were prospectively enrolled into the study. All participants underwent conventional echocardiography, as well as 2D speckle-tracking echocardiography to assess MW by non-invasive left ventricular pressure–strain and global longitudinal strain (GLS). baPWV measurements were made at the same day as the echocardiography. Then, participants were categorized according to baPWV tertiles. Correlation between baPWV and MW were analyzed. Predicting ability of baPWV for abnormal WM was analyzed using receiver operating characteristic (ROC) curve. Results The median baPWV from the low to high tertile groups were 1286.5 (1197.5–1343.5), 1490.0 (1444.5–1544.0), and 1803.8(1708.3–1972.0) cm/s, respectively. In simple linear regression analysis, baPWV had a significant positive association with global work index (GWI), global constructed work (GCW), and global wasted work (GWW), and a negative association with global work efficiency (GWE). The association remained significant after adjusting for major confounding factors in multiple linear regression analysis. The areas under the ROC curve of baPWV for predicting abnormal GWI, GCW, GWW, and GWE were 0.653, 0.666, 0.725, and 0.688, respectively (all p < 0.05). Conclusions BaPWV is significantly associated with all four components of MW using non-invasive left ventricular pressure-strain method in a mixed population of non-hypertensive and hypertensive individuals.
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Duan et al. (2022) conducted a cross-sectional in Hypertension with preserved left ventricular ejection fraction (n=208). Brachial-ankle pulse wave velocity (baPWV) vs. Lower baPWV tertiles was evaluated on Abnormal myocardial work components (GWI, GCW, GWW, and GWE) (AUC 0.653 to 0.725, p=< 0.05). Higher brachial-ankle pulse wave velocity was significantly associated with abnormal myocardial work components, with ROC AUCs ranging from 0.653 to 0.725 (all p < 0.05).
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