Key result
Noxious CNS stimulation elevating blood pressure can precipitate acute LV failure in previously damaged myocardium.
Why the study?
The mechanisms by which noxious central nervous system stimulation causes acute pulmonary edema in the setting of left ventricular myocardial insufficiency were not fully understood.
Demonstrates the pathophysiological link between central nervous system stimulation, elevated blood pressure, and acute pulmonary edema in the setting of myocardial damage.
May link CNS stress to acute edema in damaged hearts; hypothesis-generating, human validation required before clinical consideration.
Experimental evidence has indicated that the genesis of acute pulmonary edema due to insufficiency of the left ventricular myocardium is dependent upon pulmonary engorgement and rapid filtration of fluid from the capillaries. It has been possible to demonstrate that significant elevation of arterial blood pressure from noxious stimulation of the central nervous system may be poorly tolerated when the myocardium has been previously damaged, so that acute left ventricular failure has occurred. The resulting massive pulmonary edema clearly followed the hemodynamic changes of severe congestion.
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Paine et al. (1952) studied Acute pulmonary edema and left ventricular failure. Noxious stimulation of the central nervous system was evaluated on Acute left ventricular failure and massive pulmonary edema. Noxious stimulation of the central nervous system elevating arterial blood pressure can precipitate acute left ventricular failure and massive pulmonary edema when the myocardium is previously damaged.
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